Nkx3-1^tm1Saa
Targeted Allele Detail

Summary

• Symbol: Nkx3-1^tm1Saa
• Name: NK3 homeobox 1; targeted mutation 1, Sarki A Abdulkadir
• MGI ID: MGI:2447385
• Synonyms: Nkx3.1^flox
• Gene: Nkx3-1 Location: Chr14:69428141-69432107 bp, + strand Genetic Position: Chr14, 36.02 cM
• Alliance: Nkx3-1^tm1Saa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74350
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The homeodomain-containing exon 2 was flanked with a loxP site in the 3' untranslated region and a floxed PGK-neo cassette in the downstream intron via homologous recombination. (J:74350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx3-1 Mutation: 39 strains or lines available

References

• Original: J:74350 Abdulkadir SA, et al., Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol. 2002 Mar;22(5):1495-503
• All: 3 reference(s)