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Targeted Allele Detail
Symbol: Nqo2tm1Akj
Name: N-ribosyldihydronicotinamide quinone reductase 2; targeted mutation 1, Anil K Jaiswal
MGI ID: MGI:2447336
Synonyms: NQO2-
Gene: Nqo2  Location: Chr13:33964687-33988443 bp, + strand  Genetic Position: Chr13, 14.01 cM, cytoband A4
Germline Transmission:  Earliest citation of germline transmission: J:80549
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.1 kb fragment encompassing exon 3 and portions of the surrounding introns was replaced by a neo cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern or Western blot analyses of liver, kidney, testis, and lung tissue obtained from homozygous mutant mice. Assays of benzo(alpha)pyrene-sensitive Nqo2 activity showed levels to be almost completely abrogated in kidney, testes, and lung samples and reduced by approximately 80% in liver samples. The authors report that the residual activity in the liver is believed to be the result of related proteins. (J:80549)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nqo2 Mutation:  11 strains or lines available
Original:  J:80549 Long DJ 2nd, et al., Disruption of Dihydronicotinamide Riboside:Quinone Oxidoreductase 2 (NQO2) Leads to Myeloid Hyperplasia of Bone Marrow and Decreased Sensitivity to Menadione Toxicity. J Biol Chem. 2002 Nov 29;277(48):46131-9
All:  8 reference(s)

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