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Transgene Detail
Symbol: Tg(PDGFB-PSEN1M146L)2Jhd
Name: transgene insertion 2, John Hardy
MGI ID: MGI:2447326
Synonyms: PDGF-hPS1, PS1M146L, PS1(M146L), PS1-M146V, PS1mut, PS1 Tg line 6.2, PSlM146L
Transgene: Tg(PDGFB-PSEN1M146L)2Jhd  Location: unknown  
Strain of Origin:  SW x (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PDGFB-PSEN1M146L)2Jhd expresses 1 gene
Mutation detailsA PDGFB promoter fused to a human PSEN1 cDNA, which includes the intron between exons 4 and 5 and carries a methionine to leucine substitution at amino acid 146 (M146L), was used for the transgene. The PDGFB promoter was used to drive transgene expression in neurons. Transgene expression was confirmed by Northern and Western blot analysis of brain extracts derived from transgenic animals. (J:80861)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:80861 Duff K, et al., Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996 Oct 24;383(6602):710-3
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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