About   Help   FAQ
Targeted Allele Detail
Symbol: Arhgap6/Hccs/Mid1tm1Hzo
Name: midline 1; targeted mutation 1, Huda Y Zoghbi
MGI ID: MGI:2447298
Synonyms: Mid1tm1Hzo, MLS2loxP
Gene: Mid1  Location: ChrX:169685199-169990798 bp, + strand  Genetic Position: ChrX, 79.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:80528
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Intergenic deletion
Mutation detailsThe gene was replaced by a puromycin resistance gene and a loxP site in ES cells in which Arhgap6 had already been subjected to targeted mutation to replace exons 6, 7, and 8 with a neomycin resistance cassette and a loxP site. The two loxP sites are situated so that cre excision eliminates both resistance genes and all intervening DNA. All of Mid1, the entire Hccs gene, and all of Arhgap6 3' of exon 5 are thus conditionally deleted. (J:80528)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mid1 Mutation:  180 strains or lines available
Original:  J:80528 Prakash SK, et al., Loss of holocytochrome c-type synthetase causes the male lethality of X-linked dominant micro-phthalmia with linear skin defects (MLS) syndrome. Hum Mol Genet. 2002 Dec 1;11(25):3237-48
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.03
The Jackson Laboratory