Smad2^m1Mag
Chemically induced Allele Detail

Summary

• Symbol: Smad2^m1Mag
• Name: SMAD family member 2; mutation 1, Terry Magnuson
• MGI ID: MGI:2447199
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^m1Mag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80520
• Parent Cell Line: CT129 (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A C to T transition point mutation at nucleotide 886 resulted in a serine to leucine substitution at residue 276 in the Mad homology 2 domain. Phenotypic analysis suggested this allele is hypomorphic. (J:80520)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 50 strains or lines available

References

• Original: J:80520 Vivian JL, et al., An allelic series of mutations in Smad2 and Smad4 identified in a genotype-based screen of N-ethyl-N- nitrosourea-mutagenized mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15542-7
• All: 1 reference(s)