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Targeted Allele Detail
Symbol: Sox5tm1Vlf
Name: SRY (sex determining region Y)-box 5; targeted mutation 1, Veronique Lefebvre
MGI ID: MGI:2447147
Gene: Sox5  Location: Chr6:143828425-144781977 bp, - strand  Genetic Position: Chr6, 76.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:80666
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a lacZ-neo-derived cassette into the fifth coding exon of the gene corresponding to the N terminus of the coiled coil domain. Absence of gene expression in homozygous animals was confirmed by Northern blot analysis of whole embryo RNA. X-gal staining of mutant embryos revealed lacZ expression in cartilage tissue. (J:80666)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 48 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox5 Mutation:  29 strains or lines available
Original:  J:80666 Smits P, et al., The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 Aug;1(2):277-90
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory