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Tg(Thy1-APP)3Somm
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-APP)3Somm
Name: transgene insertion 3, Bernd Sommer
MGI ID: MGI:2447146
Synonyms: APP23, APP 23, TgAPP23, Tg(Thy1-APP)23/1Npa, Tg(Thy1APP)23Sdz, Tg(Thy1-APPK670N;M671L)
Transgene: Tg(Thy1-APP)3Somm  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-APP)3Somm expresses 1 gene
 
Mutation detailsA mouse Thy1 promoter and a human APP751 cDNA sequence carrying the Swedish double mutation K670N and M671L found in Alzheimer's disease patients was used for the transgene. In situ hybridization analysis of brain sections from transgenic animals showed the highest levels of transgene expression in the neocortex and hippocampus. (J:44603)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
The transgene was determined to be 7-fold over-expressed.

References
Original:  J:44603 Sturchler-Pierrat C, et al., Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13287-92
All:  116 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory