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Targeted Allele Detail
Symbol: Tshrtm1Rmar
Name: thyroid stimulating hormone receptor; targeted mutation 1, Russell Marians
MGI ID: MGI:2447142
Synonyms: TSHR-KO
Gene: Tshr  Location: Chr12:91400993-91540509 bp, + strand  Genetic Position: Chr12, 44.51 cM
Germline Transmission:  Earliest citation of germline transmission: J:80513
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe endogenous locus was disrupted by an EGFP-neo cassette inserted by homologous recombination. The absence of normal transcript and protein in homozygous mutant mice was demonstrated by RT-PCR and Western blot analyses. GFP expression was confirmed at both the transcript and protein levels. (J:80513)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tshr Mutation:  4 strains or lines available
Original:  J:80513 Marians RC, et al., Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory