Lmr30^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Lmr30^C57BL/6
• Name: leishmaniasis resistance 30; C57BL/6
• MGI ID: MGI:2446900
• QTL: Lmr30 Location: ChrX:102062606-102062720 bp Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to leishmaniasis compared to BALB/c in conjunction with Lmr1. (J:57691)
• Inheritance: Dominant

Notes

This allele, in conjunction with homozygosity for BALB/c-derived alleles at Lmr1, confers susceptibility to Leishmania major infection.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:57691

In mice, susceptibility to Leishmania major infection is genetically controlled with BALB/c mice being susceptible and C57BL/6 mice being resistant. Previous studies have revealed the presence of two QTLs Lmr1 and Lmr2 (see J:40874). Analysis of the data from the crosses implicated the presence of a X-Chromosome QTL with a dominantly acting C57BL/6 susceptibility allele. Employing a strategy to identify interacting loci, the authors were able to show that Lmr1 and Lmr2 interact synergistically as well as describe the presence of a new locus Lmr30 on the X Chromosome mapping with marker DXMit170 with a Z score of 3.9. [Fig.1.] The C57BL/6 allele at Lmr30 acts dominantly to cause susceptibility in the presence of homozygosity for the BALB/c allele at the Lmr1 locus. Tnfsf5 is a possible candidate for the Lmr30 QTL.

References

• Original: J:57691 Roberts LJ, et al., Chromosomes X, 9, and the H2 locus interact epistatically to control Leishmania major infection. Eur J Immunol. 1999 Sep;29(9):3047-50
• All: 1 reference(s)