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Targeted Allele Detail
Symbol: Trps1tm1Shiv
Name: trichorhinophalangeal syndrome I (human); targeted mutation 1, Ramesh A Shivdasani
MGI ID: MGI:2446569
Synonyms: TRPSdelta neogt
Gene: Trps1  Location: Chr15:50654752-50890463 bp, - strand  Genetic Position: Chr15, 19.18 cM
Germline Transmission:  Earliest citation of germline transmission: J:80615
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 4, which encodes the GATA-type zinc finger and 15 additional amino acids, was replaced by a floxed neomycin selection cassette inserted by homologous recombination. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Trps1tm1.1Shiv. (J:80615)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trps1 Mutation:  24 strains or lines available
Original:  J:80615 Malik TH, et al., Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec;22(24):8592-600
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory