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Targeted Allele Detail
Symbol: Ltb/Tnf/Ltatm1Dvk
Name: tumor necrosis factor; targeted mutation 1, Dmitry V Kuprash
MGI ID: MGI:2446567
Synonyms: Tnfabc-, TNF/LTDelta3
Gene: Tnf  Location: Chr17:35199381-35202007 bp, - strand  Genetic Position: Chr17, 18.59 cM
Germline Transmission:  Earliest citation of germline transmission: J:80616
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intergenic deletion
Mutation detailsAn 8.4 kb region, containing the entire Tnf gene and the last coding exons of the Lta and Ltb genes, was deleted by cre mediated recombination of surrounding loxP sites inserted within Lta and Ltb via homologous recombination. Partial coding regions of Lta and Ltb were left intact separated by a single loxP site, however RT-PCR analysis of homozygous mutant splenocytes activated by concanavalin A indicated an absence of transcript from each locus. (J:80616)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  35 strains or lines available
Original:  J:80616 Kuprash DV, et al., Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Mol Cell Biol. 2002 Dec;22(24):8626-34
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory