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Il3tm1Glli
Targeted Allele Detail
Nomenclature
Symbol: Il3tm1Glli
Name: interleukin 3; targeted mutation 1, Stephen J Galli
MGI ID: MGI:2446538
Synonyms: Il-3-
Gene: Il3  Location: Chr11:54156129-54158103 bp, - strand  Genetic Position: Chr11, 32.13 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80640
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5' portion of exon 3 was replaced by the insertion of a neomycin selection cassette. The absence of normal protein was indicated by ELISA and proliferative studies using a myeloid cell line. (J:80640)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il3 Mutation:  24 strains or lines available
References
Original:  J:80640 Mach N, et al., Involvement of interleukin-3 in delayed-type hypersensitivity. Blood. 1998 Feb 1;91(3):778-83
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory