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Reg1tm1Okam
Targeted Allele Detail
Nomenclature
Symbol: Reg1tm1Okam
Name: regenerating islet-derived 1; targeted mutation 1, Hiroshi Okamoto
MGI ID: MGI:2446480
Synonyms: Reg-
Gene: Reg1  Location: Chr6:78422711-78428667 bp, + strand  Genetic Position: Chr6, 34.77 cM, cytoband C-D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80444
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern or Western blot analyses of homozygous mutant mice. (J:80444)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Reg1 Mutation:  6 strains or lines available
References
Original:  J:80444 Unno M, et al., Production and characterization of Reg knockout mice: reduced proliferation of pancreatic beta-cells in Reg knockout mice. Diabetes. 2002 Dec;51 Suppl 3:S478-83
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory