En1^tm2(cre)Wrst
Targeted Allele Detail

Summary

• Symbol: En1^tm2(cre)Wrst
• Name: engrailed 1; targeted mutation 2, Wolfgang Wurst
• MGI ID: MGI:2446434
• Synonyms: En1^Cki, En1^Cre, En1-Cre, En1^tm6(cre)Alj
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^tm2(cre)Wrst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62572
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutation: Insertion
• En1^tm2(cre)Wrst expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	En1 (MGI:95389)

• Mutation details: A cre recombinase gene cassette was inserted into the En1 locus. A loxP flanked neomycin cassette is removed in vivo via a Cre-mediated recombination event. (J:62572)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	En1 (mouse) Summary of all recombinase alleles driven by En1. Comparative matrix view of recombinase activities Alliance mouse En1 gene page

Disease models

Expression

In Mice Carrying this Mutation:	400 assay results 10 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 32 strains or lines available

References

• Original: J:62572 Kimmel RA, et al., Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev. 2000 Jun 1;14(11):1377-89
• All: 168 reference(s)