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En1tm2(cre)Wrst
Targeted Allele Detail
Nomenclature
Symbol: En1tm2(cre)Wrst
Name: engrailed 1; targeted mutation 2, Wolfgang Wurst
MGI ID: MGI:2446434
Synonyms: En1Cki, En1Cre, En1-Cre, En1tm6(cre)Alj
Gene: En1  Location: Chr1:120602487-120607991 bp, + strand  Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62572
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Mutation detailsA cre recombinase gene cassette was inserted into the En1 locus. A loxP flanked neomycin cassette is removed in vivo via a Cre-mediated recombination event. (J:62572)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: En1     Summary of all recombinase alleles driven by En1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 129 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any En1 Mutation:  22 strains or lines available
References
Original:  J:62572 Kimmel RA, et al., Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev. 2000 Jun 1;14(11):1377-89
All:  123 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory