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Targeted Allele Detail
Symbol: Nthl1tm1Tbor
Name: nth (endonuclease III)-like 1 (E.coli); targeted mutation 1, George W Teebor
MGI ID: MGI:2446391
Synonyms: mNth1-
Gene: Nthl1  Location: Chr17:24632682-24638838 bp, + strand  Genetic Position: Chr17, 12.42 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:78429
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encompassing exons 3 and 4 was replaced with a neomycin selection cassette inserted by homologous recombination. In addition to encoding the helix-hairpin-helix motif necessary for enzyme activty, the deleted region included codon 208, encoding a lysine orthologous to human lysine 212 which is a nucleophile that initiates the formation of a Schiff base ES intermediate. RT-PCR confirmed the absence of normal transcript in homozygous mutant mice. (J:78429)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nthl1 Mutation:  5 strains or lines available
Original:  J:78429 Ocampo MT, et al., Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity. Mol Cell Biol. 2002 Sep;22(17):6111-21
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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