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Gnaqtm2Soff
Targeted Allele Detail
Nomenclature
Symbol: Gnaqtm2Soff
Name: guanine nucleotide binding protein, alpha q polypeptide; targeted mutation 2, Stefan Offermanns
MGI ID: MGI:2446355
Synonyms: gnaqflox
Gene: Gnaq  Location: Chr19:16132831-16387463 bp, + strand  Genetic Position: Chr19, 11.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77461
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 6 was left flanked by single loxP sites after a floxed neomycin selection cassette was removed via in vitro cre mediated recombination. (J:77461)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnaq Mutation:  8 strains or lines available
References
Original:  J:77461 Wettschureck N, et al., Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med. 2001 Nov;7(11):1236-40
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory