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Crkltm1Hkp
Targeted Allele Detail
Nomenclature
Symbol: Crkltm1Hkp
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Nora Heisterkamp
MGI ID: MGI:2446094
Synonyms: crkl-
Gene: Crkl  Location: Chr16:17451987-17486255 bp, + strand  Genetic Position: Chr16, 10.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76680
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. (J:76680)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crkl Mutation:  7 strains or lines available
References
Original:  J:76680 Hemmeryckx B, et al., BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl. Oncogene. 2002 May 9;21(20):3225-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory