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Targeted Allele Detail
Symbol: S100a1tm1Jhh
Name: S100 calcium binding protein A1; targeted mutation 1, Jorg Heierhorst
MGI ID: MGI:2446086
Synonyms: S100A1-
Gene: S100a1  Location: Chr3:90511034-90514392 bp, - strand  Genetic Position: Chr3, 39.24 cM, cytoband F1-F2
Germline Transmission:  Earliest citation of germline transmission: J:75781
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region was replaced with a PGK-neo cassette via homologous recombination. The absence of endogenous protein was demonstrated by Western blot and immunohistochemical analyses of homozygous mutant mice. (J:75781)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any S100a1 Mutation:  13 strains or lines available
Original:  J:75781 Du XJ, et al., Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol. 2002 Apr;22(8):2821-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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