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Transgene Detail
Symbol: Tg(Cga-LHB/CGB)94Jhn
Name: transgene insertion 94, John H Nilson
MGI ID: MGI:2446075
Synonyms: LHbetaCTP, LHbeta-CTP, LH-CTP, Tg(bLHbeta-CTP)94Jhn, Tg-LHbeta
Transgene: Tg(Cga-LHB/CGB)94Jhn  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Cga-LHB/CGB)94Jhn expresses 1 gene
Mutation detailsThe transgene contains the entire bovine luteinizing hormone beta (LHB) cDNA fused to 87 bp encoding the c-terminal peptide (CTP) of the human chorionic gonadotropin beta subunit (CGB). The bovine glycoprotein hormone alpha subunit (CGA) promoter (positions -315 to +45) was used to drive expression in gonadotropes. Immunohistochemical analysis confirmed both LHB and CTP expression in the pituitaries. (J:55157)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:55157 Risma KA, et al., Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1322-6
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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