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Tg(BGLAP-cre)1Clem
Transgene Detail
Nomenclature
Symbol: Tg(BGLAP-cre)1Clem
Name: transgene insertion 1, Thomas L Clemens
MGI ID: MGI:2446069
Synonyms: HOC-cre, OC-cre, OC-cre line 6, OCNCre, osteocalcin-Cre
Transgene: Tg(BGLAP-cre)1Clem  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA human osteocalcin (BGLAP) promoter, driving expression in osteoblasts, fused to a cre recombinase gene was used for the transgene. The cre gene was modified to include a nuclear localization signal and human ACTB 3' untranslated region. Two lines were generated, 4 and 6. This allele represents line 6. Transgene expression was observed in the calvaria, femur, and vertebrae by Northern blot analysis. (J:80190)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: BGLAP     Summary of all recombinase alleles driven by BGLAP.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 109986 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Two transgenic lines, designated 4 and 6, were established.
References
Original:  J:80190 Zhang M, et al., Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem. 2002 Nov 15;277(46):44005-12
All:  94 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory