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Targeted Allele Detail
Symbol: Hoxdtm5Ddu
Name: homeobox D cluster; targeted mutation 5, Denis Duboule
MGI ID: MGI:2445979
Synonyms: C6cre, L4
Gene: Hoxd  Location: unknown  Genetic Position: Chr2, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:45706
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsRegion IX, located in the intergenic region between Hoxd11 and Hoxd10, was disrupted by a 7 nt mutation in a nuclear receptor response element (NRRE). A floxed neo cassette that was included in the targeting construct was removed in vitro via cre mediated recombination, leaving a single loxP site downstream of region IX. (J:45706)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd Mutation:  0 strains or lines available
Original:  J:45706 Gerard M, et al., In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries. Genes Dev. 1996 Sep 15;10(18):2326-34
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory