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Transgene Detail
Symbol: Tg(K5-Ptgs2)19Kmd
Name: transgene insertion 19, Karin Muller-Decker
MGI ID: MGI:2445978
Synonyms: K5-COX-2/19, K5.COX-2/19
Transgene: Tg(K5-Ptgs2)19Kmd  Location: unknown  
Sparse hair and long nails in mice expressing Tg(K5-Ptgs2)

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  NMRI
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(K5-Ptgs2)19Kmd expresses 1 gene
Mutation detailsThe transgene is composed of a full length Ptgs2 cDNA without the 3' untranslated region fused to a bovine keratin 5 (K5) promoter. Transgene expression was confirmed by RT-PCR analysis of stratified epithelial tissues. (J:70039)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Seven founder animals were constructed and bred successfully. The founders are designated lines 4, 19, 29, 663, 667, 675, and 678. Line 19 exhibits weak transgene expression.
Original:  J:70039 Neufang G, et al., Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7629-34
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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