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Transgene Detail
Symbol: Tg(LPV-TAg121)2Tvd
Name: transgene insertion 2, Terry van Dyke
MGI ID: MGI:2445949
Synonyms: dl1137, LST1137, T121, Tg(LPV-SV40T-T121)1Tvd, TgT121, TgT(121)
Transgene: Tg(LPV-TAg121)2Tvd  Location: unknown  
Strain of Origin:  (C57BL/6J x DBA/2J)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe transgene consists of a lymphotrophic papovavirus (LPV) enhancer/early promoter and a mutant SV40 T antigen sequence truncated after amino acid 121 followed by 11 missense residues. The resulting protein includes the RB1-binding region but lacks the small t antigen and TRP53-binding region. Regulatory sequences direct expression of the transgene in B- and T-lymphocytes and choroid plexus epithelium. (J:89094)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
All transgenic mice examined at ~26 weeks of age had choroid plexus tumors. These tumors grew more slowly than similar tumors seen in transgenic mice carrying the wild-type T antigen (Tg(LPV-Tag)1Tvd).
Original:  J:72121 Saenz Robles MT, et al., Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol. 1994 Apr;14(4):2686-98
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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