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Targeted Allele Detail
Symbol: Arid5btm1Pjh
Name: AT rich interactive domain 5B (MRF1-like); targeted mutation 1, Paul J Hertzog
MGI ID: MGI:2445941
Synonyms: Desrt-
Gene: Arid5b  Location: Chr10:68092520-68278740 bp, - strand  Genetic Position: Chr10, 35.14 cM, cytoband B5.1
Germline Transmission:  Earliest citation of germline transmission: J:70658
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 98 bp exon within the AT-rich interaction domain (ARID) was replaced with a neomycin selection cassette inserted by homologous recombination. RT-PCR of RNA obtained from primary embryonic fibroblasts confirmed the removal of the targeted exon. Sequence analysis identified a resultant frameshift mutation. (J:70658)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arid5b Mutation:  108 strains or lines available
Original:  J:70658 Lahoud MH, et al., Gene targeting of desrt, a novel arid class dna-binding protein, causes growth retardation and abnormal development of reproductive organs. Genome Res. 2001 Aug;11(8):1327-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory