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Targeted Allele Detail
Symbol: Serpina5tm1Gei
Name: serine (or cysteine) peptidase inhibitor, clade A, member 5; targeted mutation 1, Margarethe Geiger
MGI ID: MGI:2445835
Synonyms: PCI-
Gene: Serpina5  Location: Chr12:104101113-104106137 bp, + strand  Genetic Position: Chr12, 53.3 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:66422
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
Mutation detailsA 3.6 kb fragment containing a portion of exon 2, exons 3 and 4, and a portion of exon 5, was replaced by with a neomycin selection cassette. No transcript was detected in the testes or ovaries of homozygous mutant mice by RT-PCR analysis. Both Western blot analysis and ELISA indicated an absence of endogenous protein in the testes of homozygous mutant mice. (J:66422)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Serpina5 Mutation:  10 strains or lines available
Original:  J:66422 Uhrin P, et al., Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest. 2000 Dec;106(12):1531-9
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory