About   Help   FAQ
Etv4tm1Hass
Targeted Allele Detail
Nomenclature
Symbol: Etv4tm1Hass
Name: ets variant 4; targeted mutation 1, John A Hassell
MGI ID: MGI:2445834
Synonyms: PEA3-, PEA3-null
Gene: Etv4  Location: Chr11:101769747-101785371 bp, - strand  Genetic Position: Chr11, 65.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66012
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence extending from within exon 6 through exon 11, including the region encoding the ETS DNA binding domain, was replaced with a neomycin selection cassette inserted by homologous recombination. Though no normal or endogenous alternatively spliced transcripts were detected in homozygous mutant mice, a stable transcript corresponding to the targeted allele was identified by RNAse protection. Normal protein was undetected by Western blot analysis of MEFs, however, the lack of an amino-terminal antibody prevented the ruling out of the presence of a truncated protein. (J:66012)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv4 Mutation:  18 strains or lines available
References
Original:  J:66012 Laing MA, et al., Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene. Mol Cell Biol. 2000 Dec;20(24):9337-45
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/12/2015
MGI 5.21
The Jackson Laboratory