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Targeted Allele Detail
Symbol: Etv4tm1Hass
Name: ets variant 4; targeted mutation 1, John A Hassell
MGI ID: MGI:2445834
Synonyms: PEA3-, PEA3-null
Gene: Etv4  Location: Chr11:101769747-101785371 bp, - strand  Genetic Position: Chr11, 65.48 cM
Germline Transmission:  Earliest citation of germline transmission: J:66012
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence extending from within exon 6 through exon 11, including the region encoding the ETS DNA binding domain, was replaced with a neomycin selection cassette inserted by homologous recombination. Though no normal or endogenous alternatively spliced transcripts were detected in homozygous mutant mice, a stable transcript corresponding to the targeted allele was identified by RNAse protection. Normal protein was undetected by Western blot analysis of MEFs, however, the lack of an amino-terminal antibody prevented the ruling out of the presence of a truncated protein. (J:66012)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv4 Mutation:  24 strains or lines available
Original:  J:66012 Laing MA, et al., Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene. Mol Cell Biol. 2000 Dec;20(24):9337-45
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.07
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