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Tg(KRT14-cre)1Amc
Transgene Detail
Nomenclature
Symbol: Tg(KRT14-cre)1Amc
Name: transgene insertion 1, Andrew P McMahon
MGI ID: MGI:2445832
Synonyms: K14cre, K14 cre, K14-cre, Krt14Cre
Transgene: Tg(KRT14-cre)1Amc  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe transgene is composed of a cre recombinase gene under the control of a human keratin 14 promoter. The human KRT14 promoter directs transgene expression in hair and skin. The transgene also contains a human growth hormone sequence and polyadenylation signal. When crossed to a transgenic reporter line, beta-galactosidase activity was detected in the oral ectoderm at 11.75 dpc, and at 14.5 dpc activity is detected in the skin and throughout the dental epithelium. (J:65294)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: KRT14     Summary of all recombinase alleles driven by KRT14.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
This allele is representative of 2 founders (#199 and #200) exhibiting the highest level of transgene expression.

Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

References
Original:  J:65294 Dassule HR, et al., Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
All:  107 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory