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Mybl2tm1Sis
Targeted Allele Detail
Nomenclature
Symbol: Mybl2tm1Sis
Name: myeloblastosis oncogene-like 2; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:2445746
Synonyms: B-myb-
Gene: Mybl2  Location: Chr2:163054687-163084688 bp, + strand  Genetic Position: Chr2, 84.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57999
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5, which encodes amino acids 94 through 167, was replaced by the insertion of a neomycin selection cassette. The deleted region encompassed portions of repeats 2 and 3 that are involved in DNA binding. Whereas this allele was observed to be homozygously lethal, similar amounts of protein were detected by Western blot analysis of wild-type and heterozygous mice. (J:57999)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mybl2 Mutation:  121 strains or lines available
References
Original:  J:57999 Tanaka Y, et al., B-myb is required for inner cell mass formation at an early stage of development. J Biol Chem. 1999 Oct 1;274(40):28067-70
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory