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Targeted Allele Detail
Symbol: Rargtm4Ipc
Name: retinoic acid receptor, gamma; targeted mutation 4, Pierre Chambon
MGI ID: MGI:2445724
Synonyms: RARgamma1-
Gene: Rarg  Location: Chr15:102234938-102257517 bp, - strand  Genetic Position: Chr15, 57.4 cM, cytoband E-F3
Germline Transmission:  Earliest citation of germline transmission: J:42773
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsAn isoform specific disruption was achieved by the insertion of a promoterless neomycin selection cassette into exon 3 via homologous recombination. Whereas gamma1 transcript was undetected by RT-PCR analysis of homozygous mutant mice, gamma2 mRNA was readily amplified. An RNAse protection assay further indicated the absence of the gamma1 isoform. (J:42773)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarg Mutation:  158 strains or lines available
Original:  J:42773 Subbarayan V, et al., Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms. Mech Dev. 1997 Aug;66(1-2):131-42
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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