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Targeted Allele Detail
Symbol: Mmp14tm1Hbh
Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Henning Birkedal-Hansen
MGI ID: MGI:2445723
Synonyms: MT1-, Mt1-MMP
Gene: Mmp14  Location: Chr14:54431612-54441265 bp, + strand  Genetic Position: Chr14, 27.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:57969
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encompassing exons 2 through 5, encoding amino acids 6 through 274, was replaced when a PGK-hprt cassette was inserted at the endogenous locus via homologous recombination. The deleted region included all but 5 residues of the prodomain and 8 residues of the catalytic domain. Northern blot analysis using probes for the amino- and carboxyl-terminal untargeted regions indicated a complete absence of transcript produced from the targeted allele. (J:57969)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 26 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  11 strains or lines available
Original:  J:57969 Holmbeck K, et al., MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell. 1999 Oct 1;99(1):81-92
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory