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Targeted Allele Detail
Symbol: Mmp14tm1Hbh
Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Henning Birkedal-Hansen
MGI ID: MGI:2445723
Synonyms: MT1-, Mt1-MMP
Gene: Mmp14  Location: Chr14:54431612-54441265 bp, + strand  Genetic Position: Chr14, 27.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:57969
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encompassing exons 2 through 5, encoding amino acids 6 through 274, was replaced when a PGK-hprt cassette was inserted at the endogenous locus via homologous recombination. The deleted region included all but 5 residues of the prodomain and 8 residues of the catalytic domain. Northern blot analysis using probes for the amino- and carboxyl-terminal untargeted regions indicated a complete absence of transcript produced from the targeted allele. (J:57969)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  24 strains or lines available
Original:  J:57969 Holmbeck K, et al., MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell. 1999 Oct 1;99(1):81-92
All:  26 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory