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Gdf10tm1Sjl
Targeted Allele Detail
Nomenclature
Symbol: Gdf10tm1Sjl
Name: growth differentiation factor 10; targeted mutation 1, Sejin Lee
MGI ID: MGI:2445719
Gene: Gdf10  Location: Chr14:33923587-33935285 bp, + strand  Genetic Position: Chr14, 20.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:56683
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the mature carboxyl terminal of the protein. Northern blot analysis indicated an absence of normal transcript in homozygous mutant mice. (J:56683)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdf10 Mutation:  29 strains or lines available
References
Original:  J:56683 Zhao R, et al., Characterization of GDF-10 expression patterns and null mice. Dev Biol. 1999 Aug 1;212(1):68-79
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory