Par5^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Par5^BALB/cJ
• Name: pulmonary adenoma resistance 5; BALB/cJ
• MGI ID: MGI:2445579
• QTL: Par5 Location: Chr18:68668300-68668468 bp Genetic Position: Chr18, Syntenic

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to pulmonary adenomas compared to SWR/J. (J:43176)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:43176

To further define the genetics of predisposition and resistance to lung cancer in mice an intercross between the intermediately, susceptible BALB/cJ strain and the highly susceptible SWR/J strain was performed. Both parental strains carry the pulmonary adenoma susceptibility 1 (Pas1) locus, a major contributor to predisposition to lung cancer.

A whole genome scan was performed on 40 of the extreme-phenotype members of the (BALB/cJ x SWR/J) F2 mice. Phenotypes were genotyped using 231 markers covering all autosomes and Chromosome X.

Significant linkage was observed on Chromosome 18, peaking at D18Mit9 with a LOD score of 7.9 which explained ~15% of the total phenotypic variance with BALB/cJ mice carrying the partially dominant resistance allele and the SWR/J mice carrying the susceptibility allele. The QTL was flanked by markers D18Mit189 and D18Mit52 (Fig.1), and was equated with a previously identified QTL labeled Par2, (Obata et al 1996, J:36219).

10.25.2014 Curator's Note: Because QTL Par2 was originally mapped using an (A/JJcl x BALB/cByJJcl) backcross in J:36219 we consider the current study a separate mapping experiment and have named this QTL Par5.

References

• Original: J:43176 Manenti G, et al., Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression. Cancer Res. 1997 Oct 1;57(19):4164-6
• All: 1 reference(s)