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Ikbkbtm2Mka
Targeted Allele Detail
Nomenclature
Symbol: Ikbkbtm2Mka
Name: inhibitor of kappaB kinase beta; targeted mutation 2, Michael Karin
MGI ID: MGI:2445462
Synonyms: Ikbk2fx, IkkBetaF, IKKBetafl, IKKbeta flox, IkkbetaloxP
Gene: Ikbkb  Location: Chr8:22659212-22706589 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80159
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted that flank exon 3, which encodes the ATP binding site of the catalytic domain. An adjacent neomycin selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. (J:82995)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  9 strains or lines available
Notes
ES cell line = GS (Genome Systems).
References
Original:  J:80159 Park JM, et al., Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 2002 Sep 20;297(5589):2048-51
All:  105 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory