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Sgk1tm1Kuhl
Targeted Allele Detail
Nomenclature
Symbol: Sgk1tm1Kuhl
Name: serum/glucocorticoid regulated kinase 1; targeted mutation 1, Dietmar Kuhl
MGI ID: MGI:2445418
Synonyms: sgk1-
Gene: Sgk1  Location: Chr10:21882184-21999903 bp, + strand  Genetic Position: Chr10, 9.83 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80115
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region containing exons 4 through 11 was deleted by in vitro cre mediated recombination of a single loxP site inserted in intron 3 and a floxed neo cassette downstream of exon 11. The deleted region encoded the entire kinase domain. A shortened transcript, corresponding to a 0.9 kb deletion, was identified in homozygous mutant mice by Northern blot analysis. (J:80115)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgk1 Mutation:  129 strains or lines available
References
Original:  J:80115 Wulff P, et al., Impaired renal Na(+) retention in the sgk1-knockout mouse. J Clin Invest. 2002 Nov;110(9):1263-8
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory