About   Help   FAQ
Hba/Nprl3tm1.1Wgw
Targeted Allele Detail
Nomenclature
Symbol: Hba/Nprl3tm1.1Wgw
Name: nitrogen permease regulator-like 3; targeted mutation 1.1, William G Wood
MGI ID: MGI:2445400
Synonyms: Maretm1.1Wgw, mHS -26-, mHS -26KO, Nprl3tm1.1Wgw
Gene: Nprl3  Location: Chr11:32225628-32267707 bp, - strand  Genetic Position: Chr11, 18.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80121
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThis allele is derived from Hba/Nprl3tm1Wgw. The floxed neo cassette was removed by mating Hba/Nprl3tm1Wgw animals to a line expressing cre recombinase very early in development. Southern blot analysis confirmed the removal of PGK-neo, leaving in its place a single loxP site. Expression of the Nprl3 gene was normal after removal of PGK-neo. No open reading frame of Nprl3 gene was disrupted. (J:80121)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nprl3 Mutation:  17 strains or lines available
References
Original:  J:80121 Anguita E, et al., Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002 Nov 15;100(10):3450-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory