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Hba/Nprl3tm1.1Wgw
Targeted Allele Detail
Nomenclature
Symbol: Hba/Nprl3tm1.1Wgw
Name: nitrogen permease regulator-like 3; targeted mutation 1.1, William G Wood
MGI ID: MGI:2445400
Synonyms: Maretm1.1Wgw, mHS -26-, mHS -26KO, Nprl3tm1.1Wgw
Gene: Nprl3  Location: Chr11:32225628-32267707 bp, - strand  Genetic Position: Chr11, 18.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80121
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThis allele is derived from Hba/Nprl3tm1Wgw. The floxed neo cassette was removed by mating Hba/Nprl3tm1Wgw animals to a line expressing cre recombinase very early in development. Southern blot analysis confirmed the removal of PGK-neo, leaving in its place a single loxP site. Expression of the Nprl3 gene was normal after removal of PGK-neo. No open reading frame of Nprl3 gene was disrupted. (J:80121)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nprl3 Mutation:  13 strains or lines available
References
Original:  J:80121 Anguita E, et al., Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype. Blood. 2002 Nov 15;100(10):3450-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory