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Selptm2Hyn
Targeted Allele Detail
Nomenclature
Symbol: Selptm2Hyn
Name: selectin, platelet; targeted mutation 2, Richard O Hynes
MGI ID: MGI:2445316
Synonyms: DeltaCT
Gene: Selp  Location: Chr1:164115264-164150026 bp, + strand  Genetic Position: Chr1, 71.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51068
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by homologous recombination of a construct containing two engineered stop codons followed by a human growth hormone (hGH) polyadenylation signal and neo. The stop codons were inserted after the first 9 nt encoding the cytoplasmic domain. In spite of the detection of both truncated and elongated transcripts by Northern blot analysis, Western blot analysis showed an absence of cytomplasmic domain peptide sequence in platelet and lung tissue lysates obtained from homozygous mutant mice. (J:51068)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Selp Mutation:  29 strains or lines available
References
Original:  J:51068 Hartwell DW, et al., Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. J Cell Biol. 1998 Nov 16;143(4):1129-41
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory