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Targeted Allele Detail
Symbol: Nxph1tm1Sud
Name: neurexophilin 1; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:2445315
Synonyms: Nph1-
Gene: Nxph1  Location: Chr6:8948431-9249032 bp, + strand  Genetic Position: Chr6, 4.38 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:51648
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted exon encoded the majority of the protein, lacking only sequence encoding the signal peptide. mRNA was undetected in homozygous mutant mice by Northern blot analysis. (J:51648)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nxph1 Mutation:  6 strains or lines available
Original:  J:51648 Missler M, et al., Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 1998 Dec 25;273(52):34716-23
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory