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Targeted Allele Detail
Symbol: Nr3c2tm1Gsc
Name: nuclear receptor subfamily 3, group C, member 2; targeted mutation 1, Gunther Schutz
MGI ID: MGI:2441654
Synonyms: MR-
Gene: Nr3c2  Location: Chr8:76899442-77245012 bp, + strand  Genetic Position: Chr8, 36.34 cM
Histological and immunocytochemical kidney analysis of Nr3c2tm1Gsc/Nr3c2tm1Gsc mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:77285
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe majority of exon 3, which encodes the first zinc finger of the DNA binding domain, was replaced with a cassette containing lacZ and neo. RT-PCR showed the presence of a fusion transcript containing lacZ in place of endogenous exon 3 sequence. (J:77285)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c2 Mutation:  20 strains or lines available
Original:  J:77285 Berger S, et al., Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9424-9
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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