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Ccr5tm1Brv
Targeted Allele Detail
Nomenclature
Symbol: Ccr5tm1Brv
Name: chemokine (C-C motif) receptor 5; targeted mutation 1, Rodrigo Bravo
MGI ID: MGI:2429994
Synonyms: ccr5-
Gene: Ccr5  Location: Chr9:124121543-124147699 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46941
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette into exon 2 via homologous recombination replaced sequence encoding all 7 transmembrane domains. Whereas mRNA transcribed from other chemokine (C-C motif) receptor loci was shown to be present at normal levels, endogenous transcript was undetected in homozygous mutant mice by Northern blot analysis. The expression of other CC-chemokine receptor genes, Ccr1, Ccr2, Ccr3, and Ccr4, was not affected. (J:46941)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccr5 Mutation:  5 strains or lines available
Notes
ES cell line = CJ7 (129S1/Sv-p+ Tyr+ Kitl+) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+).

References
Original:  J:46941 Zhou Y, et al., Impaired macrophage function and enhanced T cell-dependent immune response in mice lacking CCR5, the mouse homologue of the major HIV-1 coreceptor. J Immunol. 1998 Apr 15;160(8):4018-25
All:  4 reference(s)

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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory