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Nr4a2tm1Niko
Targeted Allele Detail
Nomenclature
Symbol: Nr4a2tm1Niko
Name: nuclear receptor subfamily 4, group A, member 2; targeted mutation 1, Vera M Nikodem
MGI ID: MGI:2429971
Synonyms: Nurr1
Gene: Nr4a2  Location: Chr2:57106830-57124003 bp, - strand  Genetic Position: Chr2, 31.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47684
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded amino acids 1 through 288, encompassing the initiating methionine and the first zinc finger domain. Transcript lacking exon 3 was detected in mutant mice by Northern blot analysis of brain tissue. Normal transcript was undetected in the substantia nigra and ventral tegmental area by in situ hybridization. (J:47684)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr4a2 Mutation:  18 strains or lines available
References
Original:  J:47684 Castillo SO, et al., Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene. Mol Cell Neurosci. 1998 May;11(1-2):36-46
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory