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Aprttm1Dwm
Targeted Allele Detail
Nomenclature
Symbol: Aprttm1Dwm
Name: adenine phosphoribosyl transferase; targeted mutation 1, David W Melton
MGI ID: MGI:2429961
Gene: Aprt  Location: Chr8:122574635-122576909 bp, - strand  Genetic Position: Chr8, 71.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38450
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing exons 1 and 2 was replaced with a neomycin selection cassette. The incorporation of labeled adenine in homozygous mutant mice was 0.5% of the wild-type level. (J:38450)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aprt Mutation:  12 strains or lines available
References
Original:  J:38450 Redhead NJ, et al., Mice with adenine phosphoribosyltransferase deficiency develop fatal 2,8-dihydroxyadenine lithiasis. Hum Gene Ther. 1996 Aug 20;7(13):1491-502
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory