Tg(RIP1-Tag)2Dh
Transgene Detail

Summary

• Symbol: Tg(RIP1-Tag)2Dh
• Name: transgene insertion 2, Douglas Hanahan
• MGI ID: MGI:2429941
• Synonyms: Rip1Tag2, RIP1-Tag2, RIP-Tag2, RT2
• Transgene: Tg(RIP1-Tag)2Dh Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Tg(RIP1-Tag)2Dh page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: 695 bp of 5' flanking DNA from the rat insulin promoter was used to drive expression of large T antigen in pancreatic beta cells. (J:50695)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(RIP1-Tag)2Dh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Four transgenic lines were produced. Transgenic mice die prematurely at 9-12 weeks of age.

References

• Original: J:50695 Hanahan D, Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature. 1985 May 9-15;315(6015):115-22
• All: 165 reference(s)