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Targeted Allele Detail
Symbol: Gktm1Wjc
Name: glycerol kinase; targeted mutation 1, William J Craigen
MGI ID: MGI:2429928
Gene: Gk  Location: ChrX:85701937-85776819 bp, - strand  Genetic Position: ChrX, 39.32 cM, cytoband C-D
Germline Transmission:  Earliest citation of germline transmission: J:43449
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encompassing all of exons 13 and 14 as well as a portion of exon 15 was replaced with a neomycin selection cassette. mRNA was undetected by Northern blot analysis of liver tissue obtained from homozygous mutant mice. A biochemical assay showed glycerol kinase activity to be reduced by over 95% in liver, kidney, and brown fat. (J:43449)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gk Mutation:  5 strains or lines available
Original:  J:43449 Huq AH, et al., X-linked glycerol kinase deficiency in the mouse leads to growth retardation, altered fat metabolism, autonomous glucocorticoid secretion and neonatal death. Hum Mol Genet. 1997 Oct;6(11):1803-9
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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