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Glb1tm1Jmat
Targeted Allele Detail
Nomenclature
Symbol: Glb1tm1Jmat
Name: galactosidase, beta 1; targeted mutation 1, Junichiro Matsuda
MGI ID: MGI:2429923
Synonyms: betaGal-
Gene: Glb1  Location: Chr9:114401078-114474379 bp, + strand  Genetic Position: Chr9, 64.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43534
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsExon 15 was disrupted by the insertion of a neomycin selection cassette. Only residual beta-galactosidase activity was detected in brain tissue obtained from homozygous mutant mice. Higher levels of residual activity were observed in spleen, testes, and renal tissues. (J:43534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glb1 Mutation:  35 strains or lines available
References
Original:  J:43534 Matsuda J, et al., Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis. Glycoconj J. 1997 Sep;14(6):729-36
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory