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Mef2atm1Eno
Targeted Allele Detail
Nomenclature
Symbol: Mef2atm1Eno
Name: myocyte enhancer factor 2A; targeted mutation 1, Eric N Olson
MGI ID: MGI:2429769
Synonyms: Mef2a-
Gene: Mef2a  Location: Chr7:67231163-67372858 bp, - strand  Genetic Position: Chr7, 36.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79973
Parent Cell Line:  KG-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe second coding exon was replaced with a neomycin selection cassette. RT-PCR confirmed the absence of normal transcript. While no normal protein was detected, a truncated protein was identified by Western blot analysis of homozygous mutant heart tissue. The mutant protein was translated from an aberrantly spliced mRNA in which exon 1 joined sequence downstream of neo. Gel mobility shift assays indicated an of ablation of endogenous DNA binding activity in homozygous mutant mice. (J:79973)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mef2a Mutation:  28 strains or lines available
References
Original:  J:79973 Naya FJ, et al., Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med. 2002 Nov;8(11):1303-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory