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Targeted Allele Detail
Symbol: Il2rgtm1Sug
Name: interleukin 2 receptor, gamma chain; targeted mutation 1, Kazuo Sugamura
MGI ID: MGI:2429736
Synonyms: CDgamma-
Gene: Il2rg  Location: ChrX:101264378-101268255 bp, - strand  Genetic Position: ChrX, 43.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:31167
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA sequence fragment containing portions of exon 7 and 8 was replaced with a neo cassette inserted by homologous recombination. The deleted region encoded the majority of the SH2-like domain. Flow cytometry and the use of labeled thymidine indicated that the mutant protein localized to the surface of thymocytes but did not transduce signals. (J:31167)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il2rg Mutation:  39 strains or lines available
ES cell line = E14.1 (129P2/OlaHsd) or EK.CCE (129S/SvEv-Gpi1c).

Original:  J:31167 Ohbo K, et al., Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood. 1996 Feb 1;87(3):956-67
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory