About   Help   FAQ
Il2rgtm1Sug
Targeted Allele Detail
Nomenclature
Symbol: Il2rgtm1Sug
Name: interleukin 2 receptor, gamma chain; targeted mutation 1, Kazuo Sugamura
MGI ID: MGI:2429736
Synonyms: CDgamma-
Gene: Il2rg  Location: ChrX:101264378-101268255 bp, - strand  Genetic Position: ChrX, 43.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31167
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA sequence fragment containing portions of exon 7 and 8 was replaced with a neo cassette inserted by homologous recombination. The deleted region encoded the majority of the SH2-like domain. Flow cytometry and the use of labeled thymidine indicated that the mutant protein localized to the surface of thymocytes but did not transduce signals. (J:31167)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il2rg Mutation:  41 strains or lines available
Notes
ES cell line = E14.1 (129P2/OlaHsd) or EK.CCE (129S/SvEv-Gpi1c).

References
Original:  J:31167 Ohbo K, et al., Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood. 1996 Feb 1;87(3):956-67
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/17/2015
MGI 5.21
The Jackson Laboratory