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Arxtm1Kki
Targeted Allele Detail
Nomenclature
Symbol: Arxtm1Kki
Name: aristaless related homeobox; targeted mutation 1, Kunio Kitamura
MGI ID: MGI:2429693
Synonyms: ArxX*
Gene: Arx  Location: ChrX:92330113-92341963 bp, + strand  Genetic Position: ChrX, 41.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79871
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a STOP-IRES-lacZ-neo cassette into exon 2, which encodes a homeobox domain. (J:79871)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 22 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Arx Mutation:  20 strains or lines available
References
Original:  J:79871 Kitamura K, et al., Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans. Nat Genet. 2002 Nov;32(3):359-69
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory