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Sox9tm2Crm
Targeted Allele Detail
Summary
Symbol: Sox9tm2Crm
Name: SRY (sex determining region Y)-box 9; targeted mutation 2, Benoit de Crombrugghe
MGI ID: MGI:2429649
Synonyms: Sox9c, Sox9flox, Sox9floxed, Sox9loxP
Gene: Sox9  Location: Chr11:112673050-112678586 bp, + strand  Genetic Position: Chr11, 77.27 cM
Alliance: Sox9tm2Crm page
Skeletal image of newborn Sox9tm2Crm/Sox9tm2Crm H2az2Tg(Wnt1-cre)11Rth/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79879
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into intron 1 and neomycin resistance gene cassette and a second loxP site were inserted downstream of exon 3. (J:79879)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 270 assay results
9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 48 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox9 Mutation:  32 strains or lines available
References
Original:  J:79879 Akiyama H, et al., The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28
All:  100 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory