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Targeted Allele Detail
Symbol: Sox9tm2Crm
Name: SRY (sex determining region Y)-box 9; targeted mutation 2, Benoit de Crombrugghe
MGI ID: MGI:2429649
Synonyms: Sox9flox, Sox9loxP
Gene: Sox9  Location: Chr11:112782224-112787760 bp, + strand  Genetic Position: Chr11, 77.27 cM
Skeletal image of newborn Sox9tm2Crm/Sox9tm2Crm H2afvTg(Wnt1-cre)11Rth/0 mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:79879
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA neomycin resistance gene was inserted downstream of exon 3 and loxP sites flanking exon 2 and neo were introduced. (J:79879)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox9 Mutation:  17 strains or lines available
Original:  J:79879 Akiyama H, et al., The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory