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Tln1tm1Crit
Targeted Allele Detail
Nomenclature
Symbol: Tln1tm1Crit
Name: talin 1; targeted mutation 1, David R Critchley
MGI ID: MGI:2429594
Synonyms: Tln1hyg, Tln1tm2Crit, Tlnhyg
Gene: Tln1  Location: Chr4:43531519-43562691 bp, - strand  Genetic Position: Chr4, 23.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65873
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a hygromycin selection cassette. Sequences corresponding to codons 37 through 66 were replaced. (J:65873)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tln1 Mutation:  92 strains or lines available
Notes
Both CGR8 and E14TG2a ES cells were injected.
References
Original:  J:65873 Monkley SJ, et al., Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory