About   Help   FAQ
Tln1tm1Crit
Targeted Allele Detail
Nomenclature
Symbol: Tln1tm1Crit
Name: talin 1; targeted mutation 1, David R Critchley
MGI ID: MGI:2429594
Synonyms: Tln1hyg, Tln1tm2Crit, Tlnhyg
Gene: Tln1  Location: Chr4:43531519-43562691 bp, - strand  Genetic Position: Chr4, 23.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65873
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a hygromycin selection cassette. Sequences corresponding to codons 37 through 66 were replaced. (J:65873)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tln1 Mutation:  96 strains or lines available
Notes
Both CGR8 and E14TG2a ES cells were injected.
References
Original:  J:65873 Monkley SJ, et al., Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/14/2017
MGI 6.08
The Jackson Laboratory