Irf1^tm1Cwe
Targeted Allele Detail

Summary

• Symbol: Irf1^tm1Cwe
• Name: interferon regulatory factor 1; targeted mutation 1, Charles Weissmann
• MGI ID: MGI:2429553
• Synonyms: IRF-1-, IRF-1⁰
• Gene: Irf1 Location: Chr11:53660841-53669200 bp, + strand Genetic Position: Chr11, 32.0 cM
• Alliance: Irf1^tm1Cwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21235
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence extending from nucleotide 752 (within exon 4) to nucleotide 1061 (within exon 6) including 308 bp of coding sequence was replaced by a cassette containing neo and a transcription terminating upstream mouse sequence (UMS). (J:21235, J:64356)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf1 Mutation: 19 strains or lines available

References

• Original: J:21235 Reis LF, et al., Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J. 1994 Oct 17;13(20):4798-806
• All: 12 reference(s)