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Irf1tm1Cwe
Targeted Allele Detail
Nomenclature
Symbol: Irf1tm1Cwe
Name: interferon regulatory factor 1; targeted mutation 1, Charles Weissmann
MGI ID: MGI:2429553
Synonyms: IRF-1-, IRF-10
Gene: Irf1  Location: Chr11:53770014-53778374 bp, + strand  Genetic Position: Chr11, 32.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:21235
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence extending from nucleotide 752 (within exon 4) to nucleotide 1061 (within exon 6) including 308 bp of coding sequence was replaced by a cassette containing neo and a transcription terminating upstream mouse sequence (UMS). (J:21235, J:64356)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf1 Mutation:  11 strains or lines available
References
Original:  J:21235 Reis LF, et al., Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J. 1994 Oct 17;13(20):4798-806
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory